Conclusions: This meta-analysis provides evidence that severe COVID-19 is associated with increased blood glucose. The combined results showed that severe COVID-19 was associated with higher blood glucose (WMD 2.21, 95% CI: 1.30-3.13, P P = 0.52). Results: Three studies reported blood glucose and HbA1c according to the severity of COVID-19 and were included in this meta-analysis. Data were pooled using a fixed- or random-effects model to calculate the weighted mean differences (WMDs) and 95% confidence intervals (CIs). Two independent researchers extracted data from eligible studies using a standardized data extraction sheet and then proceeded to cross check the results. Observational studies investigating blood glucose or glycated hemoglobin A1c (HbA1c) according to the severity of COVID-19 were considered for inclusion. Methods: PubMed, EMBASE, and Cochrane Library were searched from Decemto May 15, 2020. This meta-analysis aimed to summarize available data on the association between glycemic parameters and severity of COVID-19. However, the impact of COVID-19 on blood glucose has not been fully understood. Background: Diabetes mellitus is considered a common comorbidity of COVID-19, which has a wide spectrum of clinical manifestations ranging from asymptomatic infection to severe respiratory symptoms and even death.
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